FUNDAMENTALNAYA
I PRIKLADNAYA MATEMATIKA

(FUNDAMENTAL AND APPLIED MATHEMATICS)

2005, VOLUME 11, NUMBER 7, PAGES 207-220

**A mathematical model of the response of semicircular canal and
otolith to vestibular system rotation under gravity**

V. A. Sadovnichy

V. V. Alexandrov

E. Soto

T. B. Alexandrova

T. G. Astakhova

R. Vega

N. V. Kulikovskaya

V. I. Kurilov

S. S. Migunov

N. E. Shulenina

Abstract

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A mathematical model of the system composed of two sensors: the
semicircular canal and the sacculus, is suggested.
The model is described by three lines of blocks, each line has the
following structure: a biomechanical block,
a mechanoelectrical transduction mechanism and a block
describing the hair cell ionic currents and membrane potential
dynamics.
The response of this system to various stimuli (head rotation under
gravity and falling) is investigated.
Identification of the model parameters was done with the experimental
data obtained for the axolotl (Ambystoma tigrinum) at the Institute of
Physiology, Autonomous University of Puebla, Mexico.
Comparative analysis of the semicircular canal and sacculus membrane
potentials is presented.

Location: http://mech.math.msu.su/~fpm/eng/k05/k057/k05714h.htm

Last modified: December 14, 2005